Thursday, June 19, 2025

Week 3: Amelia

This week I continued my mouse surgeries, and we're making good progress towards a group of 20 mice with cranial windows for 2P imaging. I also attended another lab meeting, and this provided more excellent context for me about the Liston Lab's previous and ongoing work, specifically related to how depression may be related to systemic and chronic inflammation. This week I was also able to see the clinical side of the hospital for the first time. I observed two of Dr. Kaplitt's procedures: one was MRI-guided focused ultrasound (MRgFUS) ablation targeting the ventral intermediate nucleus of the thalamus for helping with tremors. The other was a bilateral implantation of a deep brain stimulator (DBS) into the globus pallidus internus (GPI), for advanced Parkinson's disease. In both of these procedures, the patient is awake so that their tremors can be assessed as the protocol goes on, and it was incredible to see the extent to which tremors decreased throughout these procedures. 

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Week 3: Eleana

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