This week included our first hands-on sessions with the two-photon microscope after doing cranial window surgeries. We’re preparing to begin actual data collection from our experimental mice over the next two weeks, and, as we were waiting for the virus, we imaged the practice mice. The Liston Lab setup is slightly different from the one i used back in Ithaca, so it was interesting to see how it works. In addition, in preparation for the data we’ll soon be generating (as long as the imaging quality in experimental mice is acceptable), we also began looking at the analysis pipeline for the calcium imaging videos that we will get.
On the clinical side, we had the chance to visit Dr. Liston’s TMS clinic. The lab currently has an ongoing clinical trial , so we got to learn more about it. The clinic works with individuals who have treatment-resistant depression, beginning with a psychiatric evaluation to assess their symptoms. Then, depending on their assigned protocol, patients receive transcranial magnetic stimulation in frequent sessions. After completing the course of stimulation, they’re re-assessed to track any changes in symptoms. The success rate of this procedure is about 50%, which I found to be promising, especially in the case of medication-resistent depression.
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