The last week of my immersion program was bittersweet. Hamilton and I finished staining the last batch of slides we received from the Histopathology Core. Samples from the two week sacrifice date seemed to display similar trends as the four week samples, with the distal region experiencing more collagen disruption compared to the midsubstance and proximal region. We are seeing disruption to a lesser degree within our sham group, which was injected with saline rather than collagenase. This disruption suggests that the shear stress placed upon the tendon/local cells during injection may play a role in tendon degradation.
We passed along remaining project details to a fellow student, who will be continuing our histology work. I spent my final day watching more arthroscopic surgery in the OR under Dr. Rodeo, marking the end of an amazing summer.
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