Friday, July 25, 2025

Week 8: MJ

This week, I continued on analyzing the bulk RNA-sequencing dataset of CD8+ T cells with human STAT3 mutations as a potential model for inclusion body myositis. I added these results to my final immersion presentation, which I presented at our weekly immersion meetings in front of my immersion peers and the immersion grant coordinators/PIs. I also attended the HSS Rheumatology journal club, where Dr. Laura Donlin, who I worked with this summer, presented a paper on how clonal hematopoiesis driven by a mutated form of the gene DNMT3A promotes inflammatory bone loss in both periodontitis and rheumatoid arthritis. This paper is important to the Donlin lab because it provides an excellent example of how somatic mutations may play a role in inflammatory and autoimmune diseases. I also shadowed Dr. David Fernandez in his Rheumatology clinic at HSS. I watched as he saw patients with various autoimmune diseases, including inclusion body myositis, lupus, and spondylitis. 

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